GHRP-6 (Growth Hormone Releasing Hexapeptide)//email@example.com
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Firstly, to clarify this peptide, GHRP-6 is a peptide a Growth Hormone Releasing hexapeptide, it’s a 28 amino acid peptide, and it works by signaling to the pituitary gland to begin secreting Growth Hormone.
Molecular Formula: C46H56N12O6
Molecular Weight: 873.01
CAS Registry Number: 87616
GHRP-6 is an injectable peptide in the category of growth hormone releasing peptides, or GHRP’s. The most common use of these peptides is to increase GH production. Other peptides in this category include GHRP-2, hexarelin, and ipamorelin. With regard to increasing GH, all of these work similarly, and there is no need or advantage to combining them. Instead, the one most suited for the particular case is chosen.
The principal use of GHRP-6 is to provide increased GH levels, which also results in increased IGF-1 levels. This aids fat loss and in some instances aids muscle gain as well. Generally, GHRP use is chosen as an alternate to GH use, and only rarely is combined with GH.
Reasons to prefer GHRP-6 over other GHRP’s are its effect on increasing appetite (which also can be a disadvantage), and its demonstrated value in reducing inflammation and helping to heal injury, particularly tendinitis.
How to Use GHRP-6:
not to eat carbs or fats 50 mins before and after a dose of GHRP-6 so as not to interfere with the GH pulse it will cause. In addition, 250mcg 3 times a day is the best dose I found to avoid overly mimicking ghrelin and still cause a large amount of muscle gain, tissue repair and fat loss.
As a peptide, GHRP-6 is one of the easiest and most affective to use. A daily dose of just 300mcg split up into 3 doses will see a marked improvement in skin tone within 3 weeks; in addition, as an Anti-aging peptide GHRP-6 tops my list of all the injectable GHRP-s.
Factors decreasing efficacy of GHRP-6
For increasing GH levels, GHRP-6 is less effective in the presence of high blood glucose levels or high somatostatin levels, which result from high IGF-1 levels. For this reason, for best effect GHRP-6 should be taken while blood sugar is relatively low, for example about 30-60 minutes before a meal. GHRP-6 will have reduced effect if GH is being taken by injection, because GH increases IGF-1. Where GH use is limited to no more than about 14 IU per week, simultaneous GHRP-6 use probably still will increase GH somewhat further, but if GH use is greater than this then likely GHRP-6 injections will do little to nothing towards increasing GH levels any further.
Low thyroid levels also decrease efficacy of GHRP-6, and modestly increased thyroid levels, such as with 50-200 mcg/day of T4, or 12.5-50 mcg/day of T3, may improve efficacy. (If T3 is used, dosage should be divided into three doses per day.)
How to use GHRP-6
GHRP-6 is most commonly provided in small vials of 5 mg, which should be stored under refrigeration. (It is acceptable however for them to be mailed unrefrigerated.) The vial is diluted with a convenient volume of sterile or bacteriostatic water. For example, the vial might be diluted with 2.5 mL of water, yielding a solution of 2 mg/mL (2000 mcg/mL.) After the water addition, the vial again will be stored under refrigeration.
When dosing, an appropriate volume will be drawn from the vial with (typically) an insulin syringe, according to the desired dose and the concentration of the preparation. In the above example, a 100 mcg dose would require only 0.05 mL, or “5 IU” as marked on an insulin syringe. A 300 mcg would require 0.15 mL, or “15 IU” as marked on an insulin syringe.
Injection may be subcutaneous, intramuscular, or intravenous according to personal preference.
Dosing will ordinarily be at least twice per day and preferably 3x/day for best effect, taken at least 30-60 minutes before a meal and at a time of non-elevated blood sugar (in other words, after blood sugar has had time to fall since the most recent meal.) The amount taken generally will be from 50-300 mcg at a time. When using a GHRH along with GHRP-6, dosing should be reduced to 50-100 mcg at a time.
For increase in GH levels, higher doses within the suggested range definitely increase effect. With regard to healing benefit, for example for tendonitis, the low end of the range is often entirely sufficient and noticeably greater effect is not necessarily seen with increased dose.
While there is no sharp cut-off between a solution of GHRP-6 still being good and having lost potency with time, as a general guideline, a vial should be used within a month of having been reconstituted. Past this, I would discard the vial and start a new one.