Oxytocin Acetate Cas No.: 50-56-6
Oxytocin Acetate EINECS : 200-048-4
Oxytocin Acetate Molecular Formula: C43H66N12O12S2
Oxytocin Acetate Molecular Weight: 1007.19
Purity (HPLC): 98.0%min.
Appearance: White powder
Single Impurity (HPLC): 1.0%max
Amino Acid Composition: ±10% of theoretical
Peptide Content (N%): >80.0%
Water Content(Karl Fischer): <6.0%
Acetate Content(HPIC): <12.0%
Mass Balance: 95.0~105.0%
Grade : Pharmaceutical Grade
Storage: Closed, below 2 ~ 8ºC preservation
Usage : For induction of labor, postpartum oxytocin, and abortion due to uterine atony or retraction caused by the bad uterus bleeding; understand the placental function reserve (oxytocin challenge test); nasal drops can promote milk ejection.
Oxytocin (Oxt) is a mammalian neurohypophysial hormone. Produced by the hypothalamus and stored and secreted by the posterior pituitary gland, oxytocin acts primarily as a neuromodulator in the brain.
Oxytocin plays an important role in the neuroanatomy of intimacy, specifically in sexual reproduction of both sexes, in particular during and after childbirth; its name, meaning “swift childbirth”, comes from Greek, oksys “swift” and , tokos “birth.” It is released in large amounts after distension of the cervix and uterus during labor, facilitating birth, maternal bonding, and, after stimulation of the nipples, lactation. Both childbirth and milk ejection result from positive feedback mechanisms.
Injected oxytocin analogues are used for labor induction and to support labor in case of difficult parturition. It has largely replaced ergometrine as the principal agent to increase uterine tone in acute postpartum hemorrhage. Oxytocin is also used in veterinary medicine to facilitate birth and to stimulate milk release. The tocolyticagent atosiban (Tractocile) acts as an antagonist of oxytocin receptors; this drug is registered in many countries to suppress premature labor between 24 and 33 weeks of gestation. It has fewer side effects than drugs previously used for this purpose (ritodrine).
Usage and dosage:
Odinopoeia or oxytocin intravenous drip, once the 2.5 – 5 units, with Sodium Chloride Injection diluted to each 1ml contains 0.01 units. Intravenous drip of the beginning of every minute of not more than 0.001 to 0.002 units, each 15 – 30 minutes increased 0.001 to 0.002 units, to achieve the contractions and normal childbirth is similar, the fastest per minute of not more than 0.02 units, usually 0.002 to 0.005 units per minute.
Control postpartum hemorrhage per minute intravenous drip of 0.02 – 0.04 units, expulsion of the placenta after intramuscular injection of 5 to 10 units.
Lactogenic just before a 2 – 3 minutes, with nasal drops a 3 drop, drop into one side or both sides of the nostril.
Preparation and specification : oxytocin injection (1) 0.5ml:2.5 units (2) 1ml:5 (3) 1ml units 10 units;
Oxytocin nasal drops 1ml:40 units. The induction of labor or prenatal uterine atony: in 2.5-5 units in 500ml 5% glucose for intravenous drip slowly (10-30 drops / minute), maximum time 20 units. (2). Prevention of postpartum hemorrhage: intramuscular injection of 5-10 on each unit, or 5% glucose solution for intravenous drip.
The main contraindication, heart disease, a caesarean history and more than three fetal maternal disable.
Oxytocin (Oxt) is a medication and hormone.As a medication, it is used to cause contraction of the uterus, which is used to start labor, increase the speed of labor, and to stop bleeding following delivery. It is used either by injection into a muscle or into a vein.
Medical uses can result in excessive contraction of the uterus that can cause distress in an unborn baby. Common side effects in the mother include nausea and a slow heart rate. Serious side effects include water intoxication with an excessive dose and uterus rupture. Allergies may also occur.
Oxytocin is normally produced in the hypothalamus and stored in the posterior pituitary gland.It plays a role in social bonding, sexual reproduction in both sexes, and during and after childbirth.It is released due to stretching of the cervix and uterus during labor and with stimulation of the nipples from breastfeeding.This helps with birth, bonding with the baby, and milk production.