Peptide Deslorelin Acetate for men

Deslorelin
Prohormones Steroids Deslorelin Acetate for Peptide Drugs 57773-65-5
Peptide Deslorelin Acetate for men (CAS: 57773-65-5)
Deslorelin acetate
Deslorelin Acetate
Sequence: GLP-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-PRO-NHEt
CAS No.: 57773-65-6
Molecular Formula: C64H83N17O12
Molecular Weight: 1282.47
Purity (HPLC): 99.0%min.
Appearance: White powder
Single Impurity (HPLC): 0.5%max
Amino Acid Composition: ± 10% of theoretical
Peptide Content (N%): ≥ 80.0%
Water Content (Karl Fischer): ≤ 8.0%
Acetate Content (HPIC): ≤ 12.0%
MS (ESI): Consistent
Mass Balance: 95.0~105.0%
Grade: Pharmaceutical Grade
Manufacturer: Hezhong
Storage: Closed, below 2 ~ 8º C preservation
Usage: Deslorelin is primarily used for the initial flare effect upon the pituitary, and its associated surge of LH secretion.

Deslorelin Acetate Description:
Deslorelin acetate is an injectable gonadotropin releasing hormone super-agonist (GnRH agonist) also known as an LHRH agonist. It stops the production of sex hormones (testosterone and oestrogen).
Deslorelin Acetate is marketed by Peptech with the brand name Ovuplant. It is currently approved for use in veterinary medicine and is used to induce ovulation in mares as part of the artificial insemination process. It is also used to stabilize high-risk pregnancies, mainly of livestock. Unlike other GnRH agonists, which are mainly used to inhibit luteinizing hormone and follicle-stimulating hormone by their ultimate downregulation of the pituitary gland, Deslorelin is primarily used for the initial flare effect upon the pituitary, and its associated surge of LH secretion.

Deslorelin Acetate Application:
Deslorelin was successfully trialed in the US and was approved for veterinary use under certain circumstances. In Europe, it was approved for use in equine assisted reproduction.
It is also being trialed in humans to study its efficacy in treatment of breast cancer in women, and in treating precocious puberty and congenital adrenal hyperplasia in male and female children.

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Gonadorelin Acetate Peptide Supply

Gonadorelin
Gonadorelin Acetate
Gonadorelin
Cas No.: 71447-49-9; 33515-09-2
Sequence: Glp-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
Product Categories:Amino Acid Derivatives;Peptide;API;peptides
Purity (HPLC): 98.0%min.
Appearance: White powder
Molecular Formula: C59H83N17O17
Molecular Weight: 1302.39
Single Impurity (HPLC): 0.5%max
Amino Acid Composition: ±10% of theoretical
Peptide Content (N%): ≥80.0%
Water Content(Karl Fischer): ≤8.0%
Acetate Content(HPIC): ≤10.0%
Specific Rotation (20/D): -55.0~-65.0°(c=1 1%HAc)
MS (ESI): Consistent
Mass Balance: 95.0~105.0%

What is Gonadorelin ?
Gonadorelin is another name for gonadotropin-releasing hormone (GnRH). It is a synthetic decapeptide prepared using solid phase peptide synthesis. GnRH is responsible for the release of follicle stimulating  hormone and leutinizing hormone from the anterior pitutitary.
GnRH is available as gonadorelin hydrochloride )and gonadorelin diacetate tetrahydrate for injectable  use. Studies have described it being used via an infusion pump system to induce ovulation in patients with hypothalamic hypogonadism. It is also used in veterinary medicine as a treatment for cattle with
cystic ovarian disease.

Application :
Gonadorelin is used to test how well the hypothalamus and the pituitary glands are working. It is also
used to cause ovulation (release of an egg from the ovary) in women who do not have regular ovulation and menstrual periods because the hypothalamus gland does not release enough GnRH.
Gonadorelin is responsible for the release of follicle stimulating hormone and leutinizing hormone from
the anterior pitutitary. In the pituitary GnRH stimulates synthesis and release of FSH and LH, a process
that is controlled by the frequency and amplitude of GnRH pulses, as well as the feedback of androgens and estrogens.
The pulsatility of GnRH secretion has been seen in all vertebrates, and it is necessary to ensure a
correct reproductive function. Thus a single hormone, GnRH, controls a complex process of follicular
growth, ovulation, and corpus luteum maintenance in the female, and spermatogenesis in the male. Its
short half life requires infusion pumps for its clinical use.

GnRH agonist peptide Triptorelin acetate

Triptorelin acetate (2mg)
Triptorelin acetate
Triptorelin Acetate
Triptorelin Acetate Product Name:Triptorelin Acetate
Triptorelin Acetate CAS No.: 57773-63-4
Triptorelin Acetate Purity (HPLC): 98.0% min.
Triptorelin Acetate Appearance: White powder
Triptorelin Acetate Sequence: Glp-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2
Triptorelin Acetate Molecular Formula: C64H82N18O13
Triptorelin Acetate Molecular Weight: 1311.46
Triptorelin Acetate Single Impurity (HPLC): 1.0%max
Triptorelin Acetate Amino Acid Composition: ±10% of theoretical
Triptorelin Acetate Peptide Content (N%): ≥80.0%
Triptorelin Acetate Water Content(Karl Fischer): ≤6.0%
Triptorelin Acetate Acetate Content (HPIC): ≤15.0%
Triptorelin Acetate MS(ESI): Consistent
Triptorelin Acetate Mass Balance: 95.0~105.0%
Triptorelin Acetate Specific Rotation (20/D): -65.0~-75.0°(c=0.5 1%HAc)

What is the Triptorelin Acetate ?
Triptorelin is a gonadotropin-releasing hormone agonist (GnRH agonist). used as the acetate or pamoate salts.
Triptorelin raises testosterone levels by causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Triptorelin is used medically for the treatment of hormone-responsive cancers such as prostate cancer or breast cancer in women. Triptorelin is marketed under the brand names Decapeptyl, Diphereline and Gonapeptyl. In the United States, it’s sold by Watson as Trelstar. Its used to cause total cessation of pituitary hormonal output, including testosterone.

Why is Triptorelin useful to a bodybuilder to restore testosterone?
If Triptorelin is used incorrectly ie; too much is used, you will end up with the same levels of testosterone as a castrated male.Triptorelin has actually been used successfully for the treatment of chemical castration of sex offenders. Its serious stuff and needs to be used with extreme caution. We’d suggest starting on a dose of 50 micrograms of Triptorelin first to see what affect it has on testosterone levels.

Triptorelin AS PCT better than HCG
In the past the options may have been clomiphene and tamoxifen. There is a significant amount of research today that illuminates the following side-effects of those SERMs: low libido, erectile dysfunction, emotional instability, ocular toxicity and hepatocellular carcinoma- just to name a few.
The other option may have been HCG. A fine option. But one that requires a very specific daily protocol, and a protocol that if not followed in a disciplined manner, may damage the endocrine system further.
Besides, GnRH is a naturally occurring neurohormone. The body does not produce clomiphene citrate, tamoxifen or *HCG naturally (*unless you are pregnant).
The problem with GnRH in the past has been that in order for it to effectively exert its actions upon the pituitary gland, several pulses over several days would need to be stimulated. These required an infusion pump in many cases. Or if too much GnRH was given it would eventually decrease pituitary secretion of gonadotropins.
After several agonists and analogues of GnRH later- we now have Triptorelin.
The research peptide Triptorelin is a decapeptide that is modeled after the hypothalamic neurohormone GnRH, that interacts with the gonadotropin-releasing hormone receptor to elicit its biologic response, the release of the pituitary hormones FSH and LH.

Adipotide Miracle Weight loss Peptide Powder

Adipotide

Adipotide (2mg)
Adipotide Miracle Weight loss Peptide Powder
Adipotide peptide Adipotide  the new King of weight loss
CAS No.:  121062-08-6
MF:  C78H111N21O19
Sequence: CKGGRAKDC-GG-D(KLAKLAK)2
Molecular formula: C111H204N36O28S2
Molar Mass: 2555.22 g/mol
Peptide Sequence: H-Cys-Lys-Gly-Gly-Arg-Ala-Lys-Asp-Cys-Gly-Gly-Asp-(Lys-Leu-Ala-Lys-Leu-Ala-Lys)2
CID 439302
Purity:  98%min
Appearance : White to off-white crystalline powder or lumps
Specific Optical Rotation (c=0.5,10% HAc) :-50.0~-60.0°
Water Content(Karl Fischer) : ≤5.0%
Acetate Content(by HPLC) : ≤15.0%
Amino Acid Composition : ±10% of theoretical
Purity (by HPLC) :≥98.0%
Single Impurity(by HPLC) :≤1.0%
Peptide Content(by %N) : ≥80%
Assay(By Anhydrous, Acetic Acid-free ) :95.0~105.0%
Bacterial Endotoxins : ≤5EU/mg
Adipotide
Aditpotide is an experimental weight loss peptidomimetic with the amino acid sequence CKGGRAKDC-GG-D(KLAKLAK)2, which has been developed by researchers in the United States in an effort to fight obesity. Peptidomimetics are small protein-like chains designed to mimic a peptide. The peptide called Adipotide has been developed by U.S. researchers in the fight against the obesity . This experimental treatment has reduced by 11% the weight of the treated monkeys by reducing fatty tissue, the BMI, and waist circumference.

Adipotide’s Advantages
Shown to promote weight loss in preclinical studies.
Shown to reduce symptoms of diabetes.
Novel mechanism compared to other therapeutics on the market or in trials.
No modulation of neurotransmitters, thus unlikely to have psychological side effects.
No amphetamine-like mechanism.
Mechanism not likely to yield GI side effects.

Aditpotide is an experimental weight loss peptidomimetic with the amino acid sequence CKGGRAKDC-GG-D(KLAKLAK)2, which has been developed by researchers in the United States in an effort to fight obesity. Peptidomimetics are small protein-like chains designed to mimic a peptide. The peptide called Adipotide has been developed by U.S. researchers in the fight against the obesity . This experimental treatment has reduced by 11% the weight of the treated monkeys by reducing fatty tissue, the BMI, and waist circumference.
Clinical Research studies have shown that the peptide-like compound, Adipotide, is able to kill fat cells thereby causing a decrease in the volume and mass of the subcutaneous fat, and this in turn leads to weight loss. Adipotide is able to kill the adipocytes (fat cells) by selectively causing programmed cell death (apoptosis) of the blood vessels supplying the adipocytes. Due to the deprivation of nutrient supply, the subsequent starvation (which causes cellular atrophy or decrease in cell size) and the accumulation of waste products in the adipocytes; an irreversible injury occurs and this leads the mitochondria to release protease enzymes called caspases (specific factors that initiate the apoptotic process) which activate the transcription (a process whereby DNA is used to create mRNA) and translation (a process whereby mRNA is used to create the nascent primary peptide) of gene sequences which ultimately leads to the production of proteins that effect the apoptotic process.

Clinical Research studies have shown that the peptide-like compound, Adipotide, is able to kill fat cells thereby causing a decrease in the volume and mass of the subcutaneous fat, and this in turn leads to weight loss. Adipotide is able to kill the adipocytes (fat cells) by selectively causing programmed cell death (apoptosis) of the blood vessels supplying the adipocytes. Due to the deprivation of nutrient supply, the subsequent starvation (which causes cellular atrophy or decrease in cell size) and the accumulation of waste products in the adipocytes; an irreversible injury occurs and this leads the mitochondria to release protease enzymes called caspases (specific factors that initiate the apoptotic process) which activate the transcription (a process whereby DNA is used to create mRNA) and translation (a process whereby mRNA is used to create the nascent primary peptide) of gene sequences which ultimately leads to the production of proteins that effect the apoptotic process.

Adipotide and Fat Loss / Weight Loss
Adipotide is an experimental treatment that prevents the blood supply to fat cells. This has helped obese monkeys to lose on average 11% of their body weight in four weeks, perhaps opening the way for therapy in humans, according to a recent research study. The study, published in the journal Science Translational Medicine , shows that body mass index and waist circumference of the rhesus monkeys were reduced.

Peptide Selank For Improving Focus Ability

Peptide Selank For Improving Focus Ability
Selank (5mg)–Synthetic derivative of the endogenous tetrapeptide Tuftsin
Selank Peptide, L-threonyl-L-lysyl-L-prolyl-L-arginyl-L-prolylglycyl-L-Proline
Selank
Common uses:
Recreationally Selank is used to improve one’s ability to focus and concentrate, reduce mental fatigue, increase mental sharpness and increase memory and learning capacity. The first noticeable effect is usually stabilization of mood and general feeling of well-being.

Neuropeptide Selank is a synthetic derivative of the human body’s naturally produced tetrapeptide Tuftsin. It is a hexapeptide whith a wide range of uses. It was first sinthesized in the late 1990’s by the Institute of Molecular Genetics of the Russian Academy of Science. Selank is used as an anxiolytic in the therapy of anxiety and phobic disorders, including generalized anxiety. Its action is similar to that of mild benzodiazepins but without the sedative effects. As a selective anxiolytic with a nootropic component, Selank can be used as treatment of depression, fear and general anxiety. It also reduces phsychic tension. This neuropeptide has passed all phases of clinical trials and is now being prepared for registration and mass production.

Selank as a nootropic
Recreationally Selank is used to improve one’s ability to focus and concentrate, reduce mental fatigue, increase mental sharpness and increase memory and learning capacity. The first noticeable effect is usually stabilization of mood and general feeling of well-being.

Selank as an antiviral agent
Selank neuropeptide also expresses immunomodulatory effects. In 2009 a study by F. Ershov et all. has evaluated antiviral properties of Selank both in vitro and in vivo against the influenza virus strain A/Aichi 2/68 (H3N2). The pronounced antiviral effect of Selank was detected in both systems. The highest efficiency – completely supressed viral reproduction was shown when Selank was added to the cell culture 24 hours before inoculation.

Selank effects
Experimental and clinical studies showed the following pharmaclogical effects of Selank:
improvement of learning and memory processes (reference, reference)
increased sensory attention
increased curiosity
increased mental clarity
restoration of balance of serotonergic and noradrenergic brain system activity (reference)
anti-anxiety – inhibition of anxiety (reference)
antiviral activity with no negative effects (reference)
psychostimulant, anti-asthenic – increased mental energy (reference)
stabilization of mood and overall feeling of wellbeing
reversal of anhedonia (restoring the feeling of pleasure)
potential restoration of catecholaminergic system functions after damage due to drug abuse reference

Selank side effects
Selank has a low toxicity profile. An overdose of 500 times higher than the normal level has been proven harmless for humans. Large majority of researchers are reporting that it is a “side effect free” compound. Some believe an overdose might cause fatigue.

Selank dosage
It’s always best to start with a low dose and gradually build up to your individual comfortable levels.
Research has shown that intranasal (nasal spray) delivery of Selank is rougly 9 times more effective than injectable. This is attributed to some of it being able to bypass the blood-brain barrier.
1. Selank as nasal spray or drops (more effective):
duration: from 10 days to as long as needed
dosage: between 400 mcg – 9 mg of Selank per day
daily frequency:total daily dosage split into 3 doses throughout the day

2. Injectable Selank use (less effective):
duration: from 10 days to as long as needed
dosage: between 250 mcg – 3 mg per day
frequency of injection:1 injection per day for low dose, 2 injections for higher dose (divided between morning and late afternoon injection)

Reconstituting (dissolving, mixing) the freeze dried Selank:
Plain sterile water for injection is the most suitable diluent for lyophilized Selank. Alternatively it can be reconstituted with bacteriostatic water (0.9% sodium chloride), normal saline (0.9% NaCl) or water containing 0.9% (9 mg/mL) of benzyl alcohol.
Freeze dried (lyophilized) Selank usually comes in 10 mg vials. Gently inject 1 to 2 ml of water into the vial. Let it sit in refrigerator for 10 – 15 minutes. If there are any undissolved particles left after 15 minutes, gently rotate the vial between your fingers until all of the powder has dissolved and you are left with clear liquid.

Injecting Selank
Selank produces systemic effect regardless of the injection spot. It can be injected subcutaneously (under the skin) or intramuscularly (into the muscle). People mostly inject it into the shoulder, tigh, buttocks or under the skin in the stomach fat area.

Preparing the Selank spray
Empty sprayer bottles can be found in local pharmacy stores or bought online (ebay, etc). If your local pharmacy doesn’t carry empty sprayers you could buy a generic nasal decongestant, discard the liquid and if the bottle is reusable, clean and reuse it.

Determining the correct dosage per spray can be tricky. Our solution was to put 3ml of water into the sprayer, then count the number of sprays while emptying it click by click. The following math is then done: total amount of mg in the selank vial divided by the total number of sprays results in how many mg’s there are per each spray.

Example: 5 mg (5000 mcg) of Selank in the vial is mixed with 1ml of water. 2 more ml of water are added to the sprayer – this makes a total of 3ml mixture which is 5mg strong. The 3ml of water results in 38 sprays (this varries from sprayer to sprayer). So the math is: 5000 mcg divided by 38 sprays = 131 mg of Selank per spray. If a person was to take 1mg (1000 mcg) per day, that would be roughly 2 sprays per nosdril, twice per day.

Storage:
If possible, always store both the freeze dried powder and the mixed solution in refrigerator (do not freeze).
Before mixing (lyophilized / freeze dried Epitalon powder):
refrigerated between 2 – 8 degrees celsius (36 – 46 Fahrenheit) it can be used for 24 months
at room temperature (up to 37 degrees Celsius or 98.6 Fahrenheit) it can be used for over 90 days
After reconstitution (liquid Selank):
liquid Selank should be refrigerated between 2 – 8 degrees celsius (36 – 46 Fahrenheit) at all times. It should not be frozen.
when in liquid form Selank should be used within 20 days

Delta sleep-inducing peptide DSIP

Delta sleep-inducing peptide DSIP
Delta sleep-inducing peptide, abbreviated DSIP, is a neuropeptide that when infused into the mesodiencephalic ventricle of recipient rabbits induces spindle and delta EEG activity and reduced motor activities.
DSIP
Product Name:Delta sleep-inducing peptide,DSIP
DSIP CAS NO:62568-57-4
DSIP Molecular Formula:C35H48N10O15
DSIP Molecular Weight:848.81
DSIP Purity:99%
DSIP Specification:2mg/vial
DSIP Grade:pharmaceutical grade

DSIP Function
Many roles for DSIP have been suggested following research carried out using peptide analogues with a greater molecular stability and through measuring DSIP-like immunological (DSIP-LI) response by injecting DSIP antiserum and antibodies

Roles in endocrine regulation
Decreases basal corticotropin level and blocks its release.
Stimulates release of luteinizing hormone (LH).
Stimulates release of somatoliberin and somatotrophin secretion and inhibits somatostatin secretion.

Structure and Interactions
DSIP is an amphiphilic peptide of molecular weight 850 daltons with the amino acid motif:N-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-C
It has been found in both free and bound forms in the hypothalamus, limbic system and pituitary as well as various peripheral organs, tissues and body fluids.[5] In the pituitary it co-localises with many peptide and non-peptide mediators such as corticotropin-like intermediate peptide (CLIP), adrenocorticotrophic hormone (ACTH), melanocyte-stimulating hormone (MSH), thyroid-stimulating hormone (TSH) and melanin concentrating hormone (MCH). It is abundant in the gut secretory cells and in the pancreas where it co-localises with glucagon.
In vitro it has been found to have a low molecular stability with a half life of only 15 minutes due to the action of a specific aminopeptidase-like enzyme.It has been suggested that in the body it complexes with carrier proteins to prevent degradation, or exists as a component of a large precursor molecule,but as yet no structure or gene has been found for this precursor.

Evidence supports the current belief that it is regulated by glucocorticoids.
Gimble et al. suggest that DSIP interacts with components of the MAPK cascade and is homologous to glucocorticoid-induced leucine zipper (GILZ).GILZ can be induced by Dexamethasone. It prevents Raf-1 activation, which inhibits phosphorylation and activation of ERK.

Roles in Disease and Medicine
Anticarcinogenic
Analgesic effect
Geroprotective effects

Enhancement Peptide Bremelanotide PT141 10mg

PT141(10mg)
Female Enhancement Peptide Bremelanotide PT141 10mg / Vial
Quick Detail:
Name : Bremelanotide, PT-141
PT-141 Cas:32780-32-8
PT-141 MF:C50H68N14O10
PT-141 Molecular Weight:1025.2
PT-141 Purity :98.0%min.
PT-141 Single Impurity (HPLC):1.0%max
PT-141 Amino Acid Composition:About 10% of theoretical
PT-141 Peptide Content (N%):80.0% min.
PT-141 Water Content(Karl Fischer):6.0%max.
PT-141 Acetate Content (HPIC):15.0%max.
PT-141 MS(ESI):Consistent
PT-141 Appearance:White powder
PT141
Description:
PT-141 is a synthetic amino acid protein discovered during clinical trials using the Melanotan 2 for sunless tanning, photo-protection results from melanotans. Participants were documented as having experienced aphrodisiac reactions, leading to the further developmentPT-141. The melanocortin system targets receptors associated with desire through the melanocyte stimulating hormone paths that cross the blood-brain-barrier. Potentially the powerful sex-drug results feeling an aphrodisiac experience amplifying arousal pt141 reviews have shown the ability to increase libido effects of both men and women.

Applications:
PT-141 functions by activating the melanocortin 1 receptor and MC4R namely. Bremelanotide originally was tested for nasal spray delivery but was discontinued after concerns about side effects. Bremelanotide PT141, as Melanotan II, may cause spontaneous arousal enhancing effect. Unlike other supplements, pt 141 results do not act on the vascular body, but directly increases desires through the nervous system.

PT-141 or Bremelanotide is the generic term for a peptide being studied for its possible use in helping to improve sexual dysfunction in both men (erectile dysfunction or impotence) and women (sexual arousal disorder). PT-141 has a similar structure to Melanotan-II and is a synthetic analogue of alpha-Melanocyte stimulating hormone (α-MSH). Alpha-MSH is an endogenous peptide that has potential influence over lipid metabolism, appetite, and sexual libido. PT-141 is a potential remedy for the treatment of sexual dysfunction and studies have shown that PT-141 does not act on the vascular system like former compounds, but allegedly works by activating melanocortin receptors in the brain, therefore helping increase ones sexual stimulation.