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Dapoxetine hydrochloride is a drug that is used to treat premature ejaculation in men. Dapoxetine hydrochloride is often developed as available by prescription and is taken orally, prior to sexual intercourse.
Dapoxetine hydrochloride Raw Powder
Dapoxetine Alias: Priligy; Dextrorotation
Dapoxetine CAS ID: 129938-20-1
Dapoxetine M. F.: C21H23NO. HCl
Dapoxetine M. W.: 341.88
Dapoxetine Assay: 99.5% by HPLC
Dapoxetine Melting point: 175~179 °C
Dapoxetine Appearance: White crystalline powder, odorless, slightly sweet, soluble in water and alcohol.
Dapoxetine is a drug used to treat premature ejaculation. It is formally known as dapoxetine hydrochloride.
Dapoxetine hydrochloride (Dextrorotation) is a drug that is used to treat premature ejaculation in men. It is available by prescription and is taken orally, prior to sexual intercourse. The drug belongs to the class called serotonin reuptake inhibitors (SSRIs), which have mainly been used to treat depression.

How Dapoxetine hydrochloride Works?
Dapoxetine works by inhibiting the serotonin transporter, increasing serotonin’s action at the post synaptic cleft, and as a consequence promoting ejaculatory delay. As a member of selective serotonin reuptake inhibitor (SSRI) family, dapoxetine was initially created as an antidepressant. However, unlike other SSRIs, dapoxetine is absorbed and eliminated rapidly in the body. Its fast acting property makes it suitable for the treatment of PE but not as an antidepressant.

Common Effects of Dapoxetine hydrochloride.
The most common effects when taking dapoxetine are nausea, dizziness, dry mouth, headache, diarrhea, and insomnia.
Discontinuation due to adverse effects is dose related. According to McMahon in recent study in Asia, the rate of discontinuation is 0.3%, 1.7%, and 5.3% of 1067 studied subjects with placebo, dapoxetine 30 mg, and dapoxetine 60 mg respectively. Unlike others SSRIs used to treat depression, which have been associated with high incidences of sexual dysfunction, dapoxetine is associated with low rates of sexual dysfunction. Taken as needed, dapoxetine has very mild adverse effects on loss of libido (<1%) and ED (<4%).

Dapoxetine hydrochloride May Cause Adverse Effects.
As with any drug, dapoxetine hydrochloride may cause adverse effects. The most common of these include dizziness, nausea, headache and diarrhea. If any untoward or serious effects are experienced, they should be discussed with the prescribing medical practitioner.

Dapoxetine hydrochloride may interact with other drugs. This is important with drugs that may bring about similar adverse effects, such as those causing hypotension, or lowered blood pressure, especially on standing up. Concomitant diseases, such as liver or renal dysfunction and some cardiac diseases, may be a contraindication to using the drug, and the prescribing doctor should be informed of other medications or conditions.

The drug should not be taken as a chronic medication or as a daily dose. It should only be taken when needed. Dapoxetine hydrochloride should be taken before sexual intercourse is desired and not more than once in a 24 hour period.

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Vardenafil is used for:
Treating erectile dysfunction (ED). It may also be used for other conditions as determined by your doctor.
Vardenafil is a phosphodiesterase type 5 (PDE5) inhibitor. It works by helping to increase blood flow into the penis during sexual stimulation. This helps you to achieve and maintain an erection.

What are the possible side effects of vardenafil (Levitra, Staxyn)?
Vardenafil may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
upset stomach
stuffy or runny nose
flu-like symptoms
During sexual activity, if you become dizzy or nauseated, or have pain, numbness, or tingling in your chest, arms, neck, or jaw, stop and call your doctor right away. You could be having a serious side effect of vardenafil.

How should this medicine be used?
Vardenafil comes as a tablet and a rapidly disintegrating (dissolves in the mouth and is swallowed without water) tablet to take by mouth. It is usually taken as needed, with or without food, 60 minutes before sexual activity. Vardenafil usually should not be taken more often than once every 24 hours. If you have certain health conditions or are taking certain medications, your doctor may tell you to take vardenafil less often.

What should I know about storage and disposal of this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

Generally speaking:
Vardenafil is an oral drug that is used to treat impotence, the inability to attain or maintain a penile erection. It has a mechanism of action that is similar to sildenafil (Viagra), and tadalafil (Cialis). Penile erection is caused by the engorgement of the penis with blood. This engorgement occurs when the blood vessels delivering blood to the penis increase in size and increase the delivery of blood to the penis. At the same time, the blood vessels carrying blood away from the penis decrease in size and decrease the removal of blood from the penis. Sexual stimulation that leads to the engorgement and erection causes the production and release of nitric oxide in the penis. Nitric oxide then activates the enzyme, guanylate cyclase to produce cyclic guanosine monophosphate (cGMP). The cGMP is primarily responsible for increasing and decreasing the size of the blood vessels carrying blood to and from the penis, respectively. Vardenafil prevents an enzyme called phosphodiesterase-5 (PDE-5) from destroying cGMP so that cGMP persists longer. The longer cGMP persists, the more prolonged the engorgement of the penis. Vardenafil was approved by the FDA in August 2003.


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Sildenafil (Viagra) is used to treat erectile dysfunction (impotence; inability to get or keep an erection) in men.
Sildenafil (Revatio) is used to improve the ability to exercise in adults with pulmonary arterial hypertension (PAH; high blood pressure in the vessels carrying blood to the lungs, causing shortness of breath, dizziness, and tiredness).
Children should not usually take sildenafil, but in some cases, a doctor may decide that sildenafil (Revatio) is the best medication to treat a child’s condition. Sildenafil is in a class of medications called phosphodiesterase (PDE) inhibitors.
Sildenafil is used for:
Treating high blood pressure in the lungs (pulmonary arterial hypertension [PAH]). It may also be used for other conditions as determined by your doctor.
Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor. It works by relaxing and dilating the blood vessels in the lungs. This lowers the blood pressure in the lungs and helps to improve your ability to exercise.

How to use Sildenafil
Sildenafil comes as a tablet and suspension (liquid; Revatio only) to take by mouth.

1:to treat erectile dysfunction, follow your doctor’s directions and the guidelines in this paragraph.
Take sildenafil as needed before sexual activity. The best time to take sildenafil is about 1 hour before sexual activity, but you can take the medication any time from 4 hours to 30 minutes before sexual activity. Sildenafil usually should not be taken more than once every 24 hours. If you have certain health conditions or are taking certain medications, your doctor may tell you to take sildenafil less often. You can take sildenafil with or without food. However, if you take sildenafil with a high-fat meal, it will take longer for the medication to start to work.

2.to treat PAH, follow your doctor’s directions and the guidelines in this paragraph.
You will probably take sildenafil three times a day with or without food. Take sildenafil at around the same times every day, and space your doses about 4 to 6 hours apart.

Do NOT use sildenafil if:
you are allergic to any ingredient in sildenafil
you have pulmonary veno-occlusive disease (PVOD)
you are taking nitrates (eg, isosorbide, nitroglycerin) in any form (eg, tablet, capsule, spray, patch, ointment) or nitroprusside
you take another medicine that contains sildenafil, another PDE5 inhibitor (eg, tadalafil, vardenafil), or ritonavir
you use certain recreational drugs called “poppers” (eg, amyl nitrate or nitrite, butyl nitrate or nitrite)
Contact your doctor or health care provider right away if any of these apply to you.


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Tadalafil under the name of Cialis is used to treat erectile dysfunction (impotence) and symptoms of benign prostatic hypertrophy (enlarged prostate).
Another brand of tadalafil is Adcirca, which is used to treat pulmonary arterial hypertension and improve exercise capacity in men and women.
Do not take Cialis while also taking Adcirca, unless your doctor tells you to.

CIALIS for daily use (5 mg) is the recommended dose to treat both ED and the symptoms of BPH. The recommended starting dose of CIALIS for daily use for the treatment of ED is 2.5 mg.
1 week to help imrove ED
You may be able to have successful intercourse in as early as 4 to 5 days
1 mongth to help BPH symptoms
You may see symptom improvement in as early as 2 weeks after beginning treatment, although it could take about 4 weeks
Take CIALIS for daily use (5 mg) once a day, every day at about the same time
CIALIS may be taken with or without meals
Do not drink alcohol in excess with CIALIS
Avoid skipping doses and do not split tablets, as you may not receive an adequate dose
What happens if I miss a dose?
If tadalafil is used as needed, you are not likely to be on a dosing schedule.
If you take tadalafil every day and you miss a dose, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.


What should I avoid while taking tadalafil?
Drinking alcohol with this medicine can cause side effects.
Grapefruit and grapefruit juice may interact with tadalafil and lead to unwanted side effects. Avoid the use of grapefruit products while taking this medicine.
Avoid using any other medicines to treat impotence, such as alprostadil or yohimbine, without first talking to your doctor.
Do not take tadalafil if you are also using a nitrate drug for chest pain or heart problems, including nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, and some recreational drugs such as “poppers”. Taking tadalafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure.

Generally speaking:
Tadalafil is PDE5 inhibitor marketed in pill form for treating erectile dysfunction (ED) under the name Cialis, and under the name Adcirca for the treatment of pulmonary arterial hypertension. In October 2011 the U.S. Food and Drug Administration (FDA) approved Cialis for treating the signs and symptoms of benign prostatic hyperplasia (BPH) as well as a combination of BPH and erectile dysfunction (ED) when the conditions coincide. It initially was developed by the biotechnology company ICOS, and then again developed and marketed world-wide by Lilly ICOS, LLC, the joint venture of ICOS Corporation and Eli Lilly and Company. Cialis tablets, in 2.5 mg, 5 mg, 10 mg, and 20 mg doses, are yellow, film-coated, and almond-shaped. The approved dose for pulmonary arterial hypertension is 40 mg (two 20-mg tablets) once daily.
Tadalafil is also manufactured and sold under the name of Tadacip by the Indian pharmaceutical company Cipla in doses of 10 mg and 20 mg.